Phospho-Nur77 (S351) Polyclonal Antibody, 100µg, (ATB-P1019)

Background: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.Product datasheet: Overview Product Description Phospho-Nur77 (S351) Polyclonal Antibody, 100µg, (ATB-P1019) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Nur77 around the phosphorylation site of S351. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: NR4A1-mediated apoptosis suppresses lymphomagenesis and is associated with a favorable cancer-specific survival in patients with aggressive B-cell lymphomas. Deutsch AJ, et al. Blood, 2014 Apr 10. PMID 24553175 The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Lee SO, et al. Mol Cancer Res, 2014 Apr. PMID 24515801 Nur77 inhibits androgen-induced bladder cancer growth. Wu J, et al. Cancer Invest, 2013 Dec. PMID 24299210 NR4A orphan nuclear receptors in glucose homeostasis: a minireview. Close AF, et al. Diabetes Metab, 2013 Dec. PMID 24075454 TR3 modulates platinum resistance in ovarian cancer. Wilson AJ, et al. Cancer Res, 2013 Aug 1. PMID 23720056 Free PMC Article A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. Nakai A., Kartha S., Sakurai A., Toback F.G., Degroot L.J.Mol. Endocrinol. 4:1438-1443(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal skeletal muscle. Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. Chang C., Kokontis J., Liao S., Chang Y.J. Steroid Biochem. 34:391-395(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Identification of an isoform of human TR3 (NGFI-B, Nur77). Ohkura N., Ito M., Tsukada T., Sasaki K., Yamaguchi K., Miki K.Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Skeletal muscle. Comprehensive DNA-binding analysis of human hormone nuclear receptors by fluorescence correlation spectroscopy based on cell-free system. Kobayashi T., Kodani Y., Sawasaki T., Endo Y.Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Isolation of cDNA coding for multiple human nuclear receptor clones. Kaighin V.A., Martin A.L., Aronstam R.S.Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Heart.