Phospho-Stat4 (Y693) Polyclonal Antibody, 100 µg, (ATB-P0252)

Background: Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.Product datasheet: Overview Product Description Species Reactivities Human,Mouse,Rat,Monkey Immunogen Synthesized peptide derived from human Stat4 around the phosphorylation site of Y693. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: The STAT amino-terminal domain mediates cooperative DNA binding and confers selective sequence recognition. Xu X., Sun Y.L., Hoey T.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. SeattleSNPs variation discovery resourceSubmitted (SEP-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 91-748. Direct interaction of STAT4 with the IL-12 receptor. Yao B.B., Niu P., Surowy C.S., Faltynek C.R.Arch. Biochem. Biophys. 368:147-155(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH IL12RB2. Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling. Naeger L.K., McKinney J., Salvekar A., Hoey T.J. Biol. Chem. 274:1875-1878(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH IL12RB2. Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. Kariuki S.N., Kirou K.A., MacDermott E.J., Barillas-Arias L., Crow M.K., Niewold T.B.J. Immunol. 182:34-38(2009) [PubMed] [Europe PMC] Cited for: INVOLVEMENT IN SLEB11. The consensus coding sequences of human breast and colorectal cancers. Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.Science 314:268-274(2006) [PubMed] [Europe PMC] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-112. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. Remmers E.F., Plenge R.M., Lee A.T., Graham R.R., Hom G., Behrens T.W., de Bakker P.I.W., Le J.M., Lee H.-S., Batliwalla F., Li W., Masters S.L., Booty M.G., Carulli J.P., Padyukov L., Alfredsson L., Klareskog L., Chen W.V. , Amos C.I., Criswell L.A., Seldin M.F., Kastner D.L., Gregersen P.K.N. Engl. J. Med. 357:977-986(2007) [PubMed] [Europe PMC] Cited for: INVOLVEMENT IN SLEB11 AND RA.