Phospho-Stat4 (Y693) Polyclonal Antibody, 100µg, (ATB-P0593)

Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.Product datasheet: Overview Product Description Phospho-Stat4 (Y693) Polyclonal Antibody, 100µg, (ATB-P0593) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Stat4 around the phosphorylation site of Y693. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: An updated meta-analysis of the signal transducer and activator of transcription 4 (STAT4) rs7574865 G/T polymorphism and rheumatoid arthritis risk in an Asian population. Jiang X, et al. Scand J Rheumatol, 2014. PMID 25179669 STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis. Joshita S, et al. Dis Markers, 2014. PMID 24648611 Free PMC Article Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco. Sabri A, et al. J Infect Dis, 2014 Aug 15. PMID 24610875 Free PMC Article Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis. Bolin K, et al. PLoS One, 2013. PMID 24386384 Free PMC Article Association of STAT4 polymorphisms with susceptibility to type-1 autoimmune hepatitis in the Japanese population. Migita K, et al. PLoS One, 2013. PMID 23990947 Free PMC Article The STAT amino-terminal domain mediates cooperative DNA binding and confers selective sequence recognition. Xu X., Sun Y.L., Hoey T.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. SeattleSNPs variation discovery resourceSubmitted (SEP-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 91-748. Direct interaction of STAT4 with the IL-12 receptor. Yao B.B., Niu P., Surowy C.S., Faltynek C.R.Arch. Biochem. Biophys. 368:147-155(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH IL12RB2. Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling. Naeger L.K., McKinney J., Salvekar A., Hoey T.J. Biol. Chem. 274:1875-1878(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH IL12RB2.