Phospho-TH (S8) Polyclonal Antibody, 100µg, (ATB-P0677)

Background: catalyzes the rate limiting step in catecholamine biosynthesis; may be involved in response to hypoxia [RGD, Feb 2006]Plays an important role in the physiology of adrenergic neurons.Product datasheet: Overview Product Description Phospho-TH (S8) Polyclonal Antibody, 100µg, (ATB-P0677) Image Species Reactivities Rat Immunogen Synthesized peptide derived from human TH around the phosphorylation site of S8. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Molecular basis of chronic stress-induced hippocampal lateral asymmetry in rats and impact on learning and memory. Spasojevic N, et al. Acta Physiol Hung, 2013 Dec. PMID 24317346 Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla. Ong LK, et al. J Neurochem, 2014 Feb. PMID 24117713 Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase. Daubner SC, et al. Biochemistry, 2013 Feb 26. PMID 23368961 Free PMC Article Males, but not females, lose tyrosine hydroxylase fibers in the medial prefrontal cortex and are impaired on a delayed alternation task during aging. Chisholm NC, et al. Behav Brain Res, 2013 Apr 15. PMID 23327742 Free PMC Article Short-term hypoxia increases phosphorylated tyrosine hydroxylase at Ser31 and Ser40 in rat carotid body. Kato K, et al. Respir Physiol Neurobiol, 2013 Feb 1. PMID 23153692 Complete coding sequence of rat tyrosine hydroxylase mRNA. Grima B., Lamouroux A., Blanot F., Faucon Biguet N., Mallet J.Proc. Natl. Acad. Sci. U.S.A. 82:617-621(1985) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Anton X.X., Manaster J.S., Kordower X.X., Markham X.X., Bredesen D.E.Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. Bienvenut W.V., von Kriegsheim A.F., Kolch W.Submitted (AUG-2006) to UniProtKBCited for: PROTEIN SEQUENCE OF 2-12; 284-298 AND 452-459, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY. Tissue: Pheochromocytoma. Tyrosine hydroxylase in rat brain dopaminergic nerve terminals. Multiple-site phosphorylation in vivo and in synaptosomes. Haycock J.W., Haycock D.A.J. Biol. Chem. 266:5650-5657(1991) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION AT SER-19; SER-31 AND SER-40. Phosphorylation of Ser(19) alters the conformation of tyrosine hydroxylase to increase the rate of phosphorylation of Ser(40). Bevilaqua L.R., Graham M.E., Dunkley P.R., von Nagy-Felsobuki E.I., Dickson P.W.J. Biol. Chem. 276:40411-40416(2001) [PubMed] [Europe PMC] Cited for: PHOSPHORYLATION AT SER-19 AND SER-40, IDENTIFICATION BY MASS SPECTROMETRY.