Phospho-TPH1 (S260) Polyclonal Antibody, 100µg, (ATB-P0748)

Background: This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]Product datasheet: Overview Product Description Phospho-TPH1 (S260) Polyclonal Antibody, 100µg, (ATB-P0748) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human TPH1 around the phosphorylation site of S260. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes. Grasberger H, et al. Am J Gastroenterol, 2013 Nov. PMID 24060757 Free PMC Article TPH1 A218C polymorphism and temperament in major depression. Andre K, et al. BMC Psychiatry, 2013 Apr 18. PMID 23597148 Free PMC Article TPH gene polymorphisms are associated with disease perception and quality of life in women with irritable bowel syndrome. Jun SE, et al. Biol Res Nurs, 2014 Jan. PMID 23172723 Free PMC Article Effect of tryptophan hydroxylase gene polymorphism on aggression in major depressive disorder and undifferentiated somatoform disorder. Koh KB, et al. J Clin Psychiatry, 2012 May. PMID 22697203 Interaction between tryptophan hydroxylase I polymorphisms and childhood abuse is associated with increased risk for borderline personality disorder in adulthood. Wilson ST, et al. Psychiatr Genet, 2012 Feb. PMID 21989108 Free PMC Article Complete coding sequence of human tryptophan hydroxylase. Boulalard S., Darmon M.C., Ganem Y., Launay J.-M., Mallet J.Nucleic Acids Res. 18:4257-4257(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Carcinoma. Cloning and expression of rabbit and human brain tryptophan hydroxylase cDNA in Escherichia coli. Tipper J.P., Citron B.A., Ribeiro P., Kaufman S.Arch. Biochem. Biophys. 315:445-453(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain. Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Alternative splicing at the 3'-cDNA of human tryptophan hydroxylase. Wang G.A., Coon S.L., Kaufman S.J. Neurochem. 71:1769-1772(1998) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 388-444 (ISOFORMS 1 AND 2).