Phospho-Troponin I-C (S43) Polyclonal Antibody, 100µg, (ATB-P0723)

Background: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.Product datasheet: Overview Product Description Phospho-Troponin I-C (S43) Polyclonal Antibody, 100µg, (ATB-P0723) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Troponin I-C around the phosphorylation site of S43. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Microvascular obstruction assessed by 3-tesla magnetic resonance imaging in acute myocardial infarction is correlated with plasma troponin I levels. Pernet K, et al. BMC Cardiovasc Disord, 2014 Apr 30. PMID 24886208 Free PMC Article The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy. Li X, et al. Heart Lung, 2014 May-Jun. PMID 24794782 Predictive value of high-sensitivity troponin-I for future adverse cardiovascular outcome in stable patients with type 2 diabetes mellitus. Yiu KH, et al. Cardiovasc Diabetol, 2014 Mar 25. PMID 24661773 Free PMC Article Cardiac troponin I in patients with chronic kidney disease stage 3 to 5 in conditions other than acute coronary syndrome. Flores-Solís LM, et al. Clin Lab, 2014. PMID 24660542 Cardiac troponin I elevation with supraventricular tachycardia: two case reports and review of the literature. Xue F, et al. BMC Res Notes, 2014 Mar 11. PMID 24618063 Free PMC Article Molecular cloning of human cardiac troponin I using polymerase chain reaction. Vallins W.J., Brand N.J., Dabhade N., Butler-Browne G., Yacoub M.H., Barton P.J.R.FEBS Lett. 270:57-61(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart muscle. Cloning and expression in Escherichia coli of the cDNA encoding human cardiac troponin I. Armour K.L., Harris W.J., Tempest P.R.Gene 131:287-292(1993) [PubMed] [Europe PMC] Cited for: SEQUENCE REVISION TO 85, NUCLEOTIDE SEQUENCE [MRNA]. Troponin I isoform expression in human heart. Hunkeler N.M., Kullman J., Murphy A.M.Circ. Res. 69:1409-1414(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Isolation and characterization of the human cardiac troponin I gene (TNNI3). Bhavsar P.K., Brand N.J., Yacoub M.H., Barton P.J.R.Genomics 35:11-23(1996) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I. Mittmann K., Jaquet K., Heilmeyer L.M.G. Jr.FEBS Lett. 273:41-45(1990) [PubMed] [Europe PMC] Cited for: PROTEIN SEQUENCE OF 11-36, ACETYLATION AT ALA-2, PHOSPHORYLATION AT SER-23 AND SER-24.