Phospho-c-Myb (S12) Polyclonal Antibody, 100µg, (ATB-P0661)

Background: This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.Product datasheet: Overview Product Description Phospho-c-Myb (S12) Polyclonal Antibody, 100µg, (ATB-P0661) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human c-Myb around the phosphorylation site of S12. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Analysis of MYB oncogene in transformed adenoid cystic carcinomas reveals distinct pathways of tumor progression. Costa AF, et al. Lab Invest, 2014 Jun. PMID 24732452 MYB gene abnormalities t(6;9) in adenoid cystic carcinoma fine-needle aspiration biopsy using fluorescence in situ hybridization. Hudson JB, et al. Arch Pathol Lab Med, 2014 Mar. PMID 24576033 MYB immunostaining is a useful ancillary test for distinguishing adenoid cystic carcinoma from pleomorphic adenoma in fine-needle aspiration biopsy specimens. Pusztaszeri MP, et al. Cancer Cytopathol, 2014 Apr. PMID 24302647 Proteome changes induced by c-myb silencing in human chronic myeloid leukemia cells suggest molecular mechanisms and putative biomarkers of hematopoietic malignancies. Di Carli M, et al. J Proteomics, 2014 Jan 16. PMID 24220303 Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics. von Holstein SL, et al. Ophthalmology, 2013 Oct. PMID 23725736 Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus. Majello B., Kenyon L.C., Dalla-Favera R.Proc. Natl. Acad. Sci. U.S.A. 83:9636-9640(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Alternative splicing of the human c-myb gene. Westin E.H., Gorse K.M., Clarke M.F.Oncogene 5:1117-1124(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Genome annotation of a 1.5 Mb region of human chromosome 6q23 encompassing a quantitative trait locus for fetal hemoglobin expression in adults. Close J.P., Game L., Clark B., Bergounioux J., Gerovassili A., Thein S.L.BMC Genomics 5:33-33(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4). Characterization of the complete sequence structure of the human c-myb gene. Westin E.H., Gorse K.M.Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 3; 4; 5 AND 6). Tissue: Liver and Placenta. Gaillard C., Perbal B.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).