Phospho-p47-phox (S328) Polyclonal Antibody, 100µg, (ATB-P1018)

Background: The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).Product datasheet: Overview Product Description Phospho-p47-phox (S328) Polyclonal Antibody, 100µg, (ATB-P1018) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human p47-phox around the phosphorylation site of S328. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Williams syndrome predisposes to vascular stiffness modified by antihypertensive use and copy number changes in NCF1. Kozel BA, et al. Hypertension, 2014 Jan. PMID 24126171 Free PMC Article Different unequal cross-over events between NCF1 and its pseudogenes in autosomal p47(phox)-deficient chronic granulomatous disease. Hayrapetyan A, et al. Biochim Biophys Acta, 2013 Oct. PMID 23688784 Defining p47-phox deficient Chronic Granulomatous Disease in a Malay family. Gill HK, et al. Asian Pac J Allergy Immunol, 2012 Dec. PMID 23393912 Diabetes, renal and cardiovascular disease in p47 phox-/- chronic granulomatous disease. Leiding JW, et al. J Clin Immunol, 2013 May. PMID 23386289 Free PMC Article Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47(phox) Phox homology (PX) domain revealed by NMR. Stampoulis P, et al. J Biol Chem, 2012 May 18. PMID 22493288 Free PMC Article Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase. Volpp B.D., Nauseef W.M., Clark R.A.Proc. Natl. Acad. Sci. U.S.A. 86:7195-7199(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. ErratumVolpp B.D., Nauseef W.M., Clark R.A.Proc. Natl. Acad. Sci. U.S.A. 86:9563-9563(1989)Cited for: SEQUENCE REVISION. Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease. Lomax K.J., Leto T.L., Nunoi H., Gallin J.I., Malech H.L.Science 245:409-412(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANTS SER-99 AND ASP-166. Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid. Rodaway A.R.F., Teahan C.G., Casimir C.M., Segal A.W., Bentley D.L.Mol. Cell. Biol. 10:5388-5396(1990) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-99 AND ASP-166. A p47-phox pseudogene carries the most common mutation causing p47-phox-deficient chronic granulomatous disease. Gorlach A., Lee P.L., Roesler J., Hopkins P.J., Christensen B., Green E.D., Chanock S.J., Curnutte J.T.J. Clin. Invest. 100:1907-1918(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-99.