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RORγ Polyclonal Antibody, 100μg, (ATB-T4167)

$199.00
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Background: The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description RORγ Polyclonal Antibody, 100μg, (ATB-T4167) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the Internal region of human RORγ. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Increased plasmacytoid dendritic cells and RORγt-expressing immune effectors in cutaneous acute graft-versus-host disease. Malard F, et al. J Leukoc Biol, 2013 Dec. PMID 23990625 Defective TH17 development in human neonatal T cells involves reduced RORC2 mRNA content. de Roock S, et al. J Allergy Clin Immunol, 2013 Sep. PMID 23726039 Rarity of human T helper 17 cells is due to retinoic acid orphan receptor-dependent mechanisms that limit their expansion. Santarlasci V, et al. Immunity, 2012 Feb 24. PMID 22326581 Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Jin L, et al. Mol Endocrinol, 2010 May. PMID 20203100 Free PMC Article The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells. Crome SQ, et al. Eur J Immunol, 2009 Jun. PMID 19449310

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RORγ Polyclonal Antibody, 100μg, (ATB-T4167)
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