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RUNX3 Polyclonal Antibody, 100μg, (ATB-T4193)

$199.00
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Product Details

Background: This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description RUNX3 Polyclonal Antibody, 100μg, (ATB-T4193) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human RUNX3. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Clinicopathological significance of RUNX3 gene hypermethylation in hepatocellular carcinoma. Yang Y, et al. Tumour Biol, 2014 Oct. PMID 25037468 Expression of RUNX3 gene in pancreatic adenocarcinoma and its clinical significance. Xue LN, et al. Genet Mol Res, 2014 May 23. PMID 24938604 RUNX3 facilitates growth of Ewing sarcoma cells. Bledsoe KL, et al. J Cell Physiol, 2014 Dec. PMID 24812032 Overexpression of RUNX3 inhibits malignant behaviour of Eca109 cells in vitro and vivo. Chen HX, et al. Asian Pac J Cancer Prev, 2014. PMID 24641363 Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells. Ju X, et al. Cancer Sci, 2014 Apr. PMID 24447505

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RUNX3 Polyclonal Antibody, 100μg, (ATB-T4193)
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