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Rab 6A Polyclonal Antibody, 100μg, (ATB-T3937)

$199.00
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Background: This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]Product datasheet: Overview Product Description Rab 6A Polyclonal Antibody, 100μg, (ATB-T3937) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human Rab 6A. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA. Chen Y, et al. Infect Immun, 2013 Jun. PMID 23569112 Free PMC Article Crystal structure of Rab6A'(Q72L) mutant reveals unexpected GDP/Mg²⁺ binding with opened GTP-binding domain. Shin YC, et al. Biochem Biophys Res Commun, 2012 Jul 27. PMID 22750005 Rab6 is a modulator of the unfolded protein response: implications for Alzheimer's disease. Elfrink HL, et al. J Alzheimers Dis, 2012. PMID 22124028 Rab and actomyosin-dependent fission of transport vesicles at the Golgi complex. Miserey-Lenkei S, et al. Nat Cell Biol, 2010 Jul. PMID 20562865 Rab6 regulates transport and targeting of exocytotic carriers. Grigoriev I, et al. Dev Cell, 2007 Aug. PMID 17681140

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Rab 6A Polyclonal Antibody, 100μg, (ATB-T3937)
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