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Rad51D Polyclonal Antibody, 100μg, (ATB-T3968)

$199.00
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Product Details

Background: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]Product datasheet: Overview Product Description Rad51D Polyclonal Antibody, 100μg, (ATB-T3968) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human Rad51D. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: About 1% of the breast and ovarian Spanish families testing negative for BRCA1 and BRCA2 are carriers of RAD51D pathogenic variants. Gutiérrez-Enríquez S, et al. Int J Cancer, 2014 May 1. PMID 24130102 Analysis of RAD51D in ovarian cancer patients and families with a history of ovarian or breast cancer. Thompson ER, et al. PLoS One, 2013. PMID 23372765 Free PMC Article Loss of function germline mutations in RAD51D in women with ovarian carcinoma. Wickramanayake A, et al. Gynecol Oncol, 2012 Dec. PMID 22986143 Free PMC Article A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer. Pelttari LM, et al. J Med Genet, 2012 Jul. PMID 22652533 Mutation analysis of RAD51D in non-BRCA1/2 ovarian and breast cancer families. Osher DJ, et al. Br J Cancer, 2012 Apr 10. PMID 22415235 Free PMC Article

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Rad51D Polyclonal Antibody, 100μg, (ATB-T3968)
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