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Ribosomal Protein L10A Polyclonal Antibody, 100μg, (ATB-T4092)
Background: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Ribosomal Protein L10A Polyclonal Antibody, 100μg, (ATB-T4092) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human Ribosomal Protein L10A. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. Koga M, et al. Tissue Antigens, 2003 Feb. PMID 12694581 The primary structure of rat ribosomal protein L10a. Olvera J, et al. Biochem Biophys Res Commun, 1996 Mar 27. PMID 8607874 Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19. Fisicaro N, et al. Mol Immunol, 1995 Jun. PMID 7609734 Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. Tripodis N, et al. Genome Res, 1998 Jun. PMID 9647638 Free PMC Article Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease. Martin I, et al. Cell, 2014 Apr 10. PMID 24725412
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