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Ribosomal Protein S19 Polyclonal Antibody, 100μg, (ATB-T4126)
Background: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Ribosomal Protein S19 Polyclonal Antibody, 100μg, (ATB-T4126) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human Ribosomal Protein S19. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Ribosomal protein S19-binding domain provides insights into hantavirus nucleocapsid protein-mediated translation initiation mechanism. Ganaie SS, et al. Biochem J, 2014 Nov 15. PMID 25062117 5'UTR variants of ribosomal protein S19 transcript determine translational efficiency: implications for Diamond-Blackfan anemia and tissue variability. Badhai J, et al. PLoS One, 2011 Mar 11. PMID 21412415 Free PMC Article Characterization of the Interaction between hantavirus nucleocapsid protein (N) and ribosomal protein S19 (RPS19). Cheng E, et al. J Biol Chem, 2011 Apr 1. PMID 21296889 Free PMC Article Ribosomal protein S19 binds to its own mRNA with reduced affinity in Diamond-Blackfan anemia. Schuster J, et al. Blood Cells Mol Dis, 2010 Jun 15. PMID 20395159 Free PMC Article Genetic variants in the noncoding region of RPS19 gene in Diamond-Blackfan anemia: potential implications for phenotypic heterogeneity. Crétien A, et al. Am J Hematol, 2010 Feb. PMID 20054847
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