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Ribosomal Protein S6 Polyclonal Antibody, 100μg, (ATB-T4140)
Background: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Ribosomal Protein S6 Polyclonal Antibody, 100μg, (ATB-T4140) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Ribosomal Protein S6 around the non-phosphorylation site of S235/S236. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers. Sun CK, et al. Oncotarget, 2014 May 30. PMID 24831086 Free PMC Article Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia. Pinto AP, et al. Mod Pathol, 2013 Nov. PMID 23765247 Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma. Kim SH, et al. Mod Pathol, 2013 Mar. PMID 22996377 A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Castellani RJ, et al. Lab Invest, 2011 Dec. PMID 21968813 Free PMC Article pS6 Expression in normal renal parenchyma, primary renal cell carcinomas and their metastases. Hager M, et al. Pathol Oncol Res, 2012 Apr. PMID 21792700
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
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