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SCYL1BP1 Polyclonal Antibody, 100μg, (ATB-T15369)

$199.00
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Background: This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]Product datasheet: Overview Product Description SCYL1BP1 Polyclonal Antibody, 100μg, (ATB-T15369) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human SCYL1BP1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: A novel missense mutation in SCYL1BP1 produces geroderma osteodysplastica phenotype indistinguishable from that caused by nullimorphic mutations. Al-Dosari M, et al. Am J Med Genet A, 2009 Oct. PMID 19681135 Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin. Hennies HC, et al. Nat Genet, 2008 Dec. PMID 18997784 Free PMC Article A new human gene hNTKL-BP1 interacts with hPirh2. Zhang L, et al. Biochem Biophys Res Commun, 2005 Apr 29. PMID 15781263 Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination. Yan J, et al. FEBS Lett, 2010 Oct 22. PMID 20849854 Free PMC Article CK beta 8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKC delta/NF-kappa B and is involved in inflammatory responses. Kim J, et al. Life Sci, 2010 Feb 27. PMID 19951712

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SCYL1BP1 Polyclonal Antibody, 100μg, (ATB-T15369)
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