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SIRT2 Polyclonal Antibody, 100μg, (ATB-T4303)

$199.00
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Product Details

Background: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]Product datasheet: Overview Product Description SIRT2 Polyclonal Antibody, 100μg, (ATB-T4303) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human SIRT2. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: [SIRT2, a multi-talented deacetylase]. Sayd S, et al. Med Sci (Paris), 2014 May. PMID 24939540 Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease. Patel VP, et al. Exp Neurol, 2014 Jul. PMID 24792244 The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease: a meta-analysis. Wei W, et al. Neuromolecular Med, 2014 Jun. PMID 24497179 SIRT2: tumour suppressor or tumour promoter in operable breast cancer? McGlynn LM, et al. Eur J Cancer, 2014 Jan. PMID 24183459 Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform. Rack JG, et al. J Mol Biol, 2014 Apr 17. PMID 24177535

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SIRT2 Polyclonal Antibody, 100μg, (ATB-T4303)
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