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SLP-76 Polyclonal Antibody, 100μg, (ATB-T4321)
Background: SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description SLP-76 Polyclonal Antibody, 100μg, (ATB-T4321) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human SLP-76 around the non-phosphorylation site of Y128. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation. Liu H, et al. J Biol Chem, 2013 Oct 11. PMID 23935094 Free PMC Article Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells. Cao L, et al. PLoS One, 2012. PMID 23071622 Free PMC Article Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells. Kim HS, et al. Sci Signal, 2012 Jul 10. PMID 22786724 Free PMC Article SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK. Bogin Y, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17420479 Free PMC Article Retinoic acid induces expression of SLP-76: expression with c-FMS enhances ERK activation and retinoic acid-induced differentiation/G0 arrest of HL-60 cells. Yen A, et al. Eur J Cell Biol, 2006 Feb. PMID 16439309
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At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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