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SMIF Polyclonal Antibody, 100μg, (ATB-T4343)

$199.00
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Product Details

Background: Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]Product datasheet: Overview Product Description SMIF Polyclonal Antibody, 100μg, (ATB-T4343) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the Internal region of human SMIF. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The P body protein Dcp1a is hyper-phosphorylated during mitosis. Aizer A, et al. PLoS One, 2013. PMID 23300942 Free PMC Article Lafora disease E3 ubiquitin ligase malin is recruited to the processing bodies and regulates the microRNA-mediated gene silencing process via the decapping enzyme Dcp1a. Singh S, et al. RNA Biol, 2012 Dec 1. PMID 23131811 Dcp1-bodies in mouse oocytes. Swetloff A, et al. Mol Biol Cell, 2009 Dec. PMID 19812249 Free PMC Article An EVH1/WH1 domain as a key actor in TGFbeta signalling. Callebaut I. FEBS Lett, 2002 May 22. PMID 12023040 The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Chang CT, et al. Nucleic Acids Res, 2014 Apr. PMID 24510189 Free PMC Article

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SMIF Polyclonal Antibody, 100μg, (ATB-T4343)
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