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SNRPN Polyclonal Antibody, 100μg, (ATB-T15457)
Background: The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description SNRPN Polyclonal Antibody, 100μg, (ATB-T15457) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human SNRPN. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Modulation of alternative splicing by expression of small nuclear ribonucleoprotein polypeptide N. Lee MS, et al. FEBS J, 2014 Dec. PMID 25238490 Copy number variations at the Prader-Willi syndrome region on chromosome 15 and associations with obesity in whites. Chen Y, et al. Obesity (Silver Spring), 2011 Jun. PMID 21233802 Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells. Lee SH, et al. J Neurooncol, 2011 Feb. PMID 20582452 Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos. Geuns E, et al. Hum Mol Genet, 2003 Nov 15. PMID 14500540 A novel MSP/DHPLC method for the investigation of the methylation status of imprinted genes enables the molecular detection of low cell mosaicisms. Baumer A, et al. Hum Mutat, 2001 May. PMID 11317358
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At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
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