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SNX1 Polyclonal Antibody, 100μg, (ATB-T4358)

$199.00
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Background: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description SNX1 Polyclonal Antibody, 100μg, (ATB-T4358) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human SNX1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma. Huang Z, et al. Cancer Res, 2011 Apr 1. PMID 21427358 Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection. Bujny MV, et al. J Cell Sci, 2008 Jun 15. PMID 18505799 Sorting nexin 1 down-regulation promotes colon tumorigenesis. Nguyen LN, et al. Clin Cancer Res, 2006 Dec 1. PMID 17145813 Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Carlton J, et al. Curr Biol, 2004 Oct 26. PMID 15498486 Endosomal localization and function of sorting nexin 1. Zhong Q, et al. Proc Natl Acad Sci U S A, 2002 May 14. PMID 11997453 Free PMC Article

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SNX1 Polyclonal Antibody, 100μg, (ATB-T4358)
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