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SP-A Polyclonal Antibody, 100μg, (ATB-T15191)

$199.00
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Product Details

Background: This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]Product datasheet: Overview Product Description SP-A Polyclonal Antibody, 100μg, (ATB-T15191) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human SP-A. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. Noutsios GT, et al. Am J Physiol Lung Cell Mol Physiol, 2013 Jun 1. PMID 23525782 Free PMC Article Allelic mRNA expression imbalance in C-type lectins reveals a frequent regulatory SNP in the human surfactant protein A (SP-A) gene. Azad AK, et al. Genes Immun, 2013 Mar. PMID 23328842 Free PMC Article Human surfactant protein A2 gene mutations impair dimmer/trimer assembly leading to deficiency in protein sialylation and secretion. Song Y, et al. PLoS One, 2012. PMID 23056344 Free PMC Article The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. Silveyra P, et al. Am J Physiol Lung Cell Mol Physiol, 2011 Nov. PMID 21840962 Free PMC Article Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. Maitra M, et al. J Biol Chem, 2010 Jul 16. PMID 20466729 Free PMC Article

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SP-A Polyclonal Antibody, 100μg, (ATB-T15191)
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