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SRF Polyclonal Antibody, 100μg, (ATB-T4416)

$199.00
In stock
Product Details

Background: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]Product datasheet: Overview Product Description SRF Polyclonal Antibody, 100μg, (ATB-T4416) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human SRF around the non-phosphorylation site of S77. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases. O'Hurley G, et al. Prostate, 2014 Feb. PMID 24249383 Serum response factor induces epithelial to mesenchymal transition with resistance to sorafenib in hepatocellular carcinoma. Bae JS, et al. Int J Oncol, 2014 Jan. PMID 24173109 Expression of serum response factor in gastric carcinoma and its molecular mechanisms involved in the regulation of the invasion and migration of SGC-7901 cells. Zhao M, et al. Cancer Biother Radiopharm, 2013 Mar. PMID 23134219 Weak up-regulation of serum response factor in gastric ulcers in patients with co-morbidities is associated with increased risk of recurrent bleeding. Cheng HC, et al. BMC Gastroenterol, 2011 Mar 16. PMID 21410985 Free PMC Article Nuclear import of serum response factor in airway smooth muscle. McConville JF, et al. Am J Respir Cell Mol Biol, 2011 Sep. PMID 21131446 Free PMC Article

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SRF Polyclonal Antibody, 100μg, (ATB-T4416)
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