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SRPK1 Polyclonal Antibody, 100μg, (ATB-T4422)

$199.00
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Background: This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined.[provided by RefSeq, Jul 2010]Product datasheet: Overview Product Description SRPK1 Polyclonal Antibody, 100μg, (ATB-T4422) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human SRPK1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Human papillomavirus type 1 E1^E4 protein is a potent inhibitor of the serine-arginine (SR) protein kinase SRPK1 and inhibits phosphorylation of host SR proteins and of the viral transcription and replication regulator E2. Prescott EL, et al. J Virol, 2014 Nov. PMID 25142587 Recruiting a silent partner for activation of the protein kinase SRPK1. Aubol BE, et al. Biochemistry, 2014 Jul 22. PMID 24984036 Splicing kinase SRPK1 conforms to the landscape of its SR protein substrate. Aubol BE, et al. Biochemistry, 2013 Oct 29. PMID 24074032 Free PMC Article SRPK1 contributes to malignancy of hepatocellular carcinoma through a possible mechanism involving PI3K/Akt. Zhou B, et al. Mol Cell Biochem, 2013 Jul. PMID 23644876 Distribution of SRPK1 in human brain. Mytilinaios DG, et al. J Chem Neuroanat, 2012 Jan. PMID 22019390

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SRPK1 Polyclonal Antibody, 100μg, (ATB-T4422)
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