Skp2 p45 Polyclonal Antibody, 100μg, (ATB-T4311)

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]Product datasheet: Overview Product Description Skp2 p45 Polyclonal Antibody, 100μg, (ATB-T4311) Image Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human Skp2 p45. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells. Liao YJ, et al. Cell Death Dis, 2014 Mar 20. PMID 24651440 Free PMC Article Acquisition of epithelial-mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells. Yang Q, et al. Br J Cancer, 2014 Apr 15. PMID 24642627 SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential. Tian YF, et al. Tumour Biol, 2013 Apr. PMID 23328995 Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. Wang Z, et al. Oncotarget, 2012 Nov. PMID 23230084 Free PMC Article Downregulation of Skp2 inhibits the growth and metastasis of gastric cancer cells in vitro and in vivo. Wei Z, et al. Tumour Biol, 2013 Feb. PMID 23229098