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Smad1 Polyclonal Antibody, 100μg, (ATB-T15347)
Background: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Smad1 Polyclonal Antibody, 100μg, (ATB-T15347) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Smad1 around the non-phosphorylation site of S214. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Urinary Smad1 is a new biomarker for diagnosis and evaluating the severity of diabetic nephropathy. Li Q, et al. Endocrine, 2014 May. PMID 23943254 [BMP4-Smad1 signaling pathway in pathogenesis of diabetic nephropathy]. Abe H, et al. Nihon Jinzo Gakkai Shi, 2011. PMID 22073863 Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment. Cook BD, et al. Blood, 2011 Jun 16. PMID 21515822 Free PMC Article Modification of Smad1 linker modulates BMP-mediated osteogenesis of adult human MSC. Skarżyńska J, et al. Connect Tissue Res, 2011 Oct. PMID 21405981 Role of Smad1 in diabetic nephropathy: Molecular mechanisms and implications as a diagnostic marker. Abe H, et al. Histol Histopathol, 2011 Apr. PMID 21360446
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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