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Somatotropin Polyclonal Antibody, 100μg, (ATB-T4366)

$199.00
In stock
Product Details

Background: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Somatotropin Polyclonal Antibody, 100μg, (ATB-T4366) Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human Somatotropin. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The influence of growth hormone on bone and adipose programming. Oberbauer AM. Adv Exp Med Biol, 2014. PMID 25015810 Clinical predictors of GH deficiency in surgically cured acromegalic patients. Ku CR, et al. Eur J Endocrinol, 2014 Sep. PMID 24972779 Extrapituitary growth hormone synthesis in humans. Pérez-Ibave DC, et al. Growth Horm IGF Res, 2014 Apr-Jun. PMID 24642386 Novel mutations in the GH gene (GH1) uncover putative splicing regulatory elements. Babu D, et al. Endocrinology, 2014 May. PMID 24635352 Thiol-disulfide exchange in peptides derived from human growth hormone. Chandrasekhar S, et al. J Pharm Sci, 2014 Apr. PMID 24549831 Free PMC Article

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Somatotropin Polyclonal Antibody, 100μg, (ATB-T4366)
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