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TANK Polyclonal Antibody, 100μg, (ATB-T4540)

$199.00
In stock
Product Details

Background: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]Product datasheet: Overview Product Description TANK Polyclonal Antibody, 100μg, (ATB-T4540) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human TANK. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: TRAF family member-associated NF-KB activator (TANK) gene polymorphism in chronic periodontitis and peri-implantitis patients. Kadkhodazadeh M, et al. J Long Term Eff Med Implants, 2012. PMID 23428248 Association of a TANK gene polymorphism with outcomes of hepatitis B virus infection in a Chinese Han population. Song QL, et al. Viral Immunol, 2012 Feb. PMID 22225470 TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation. Bonif M, et al. Biochem J, 2006 Mar 15. PMID 16336209 Free PMC Article Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women. Ishida R, et al. Bone, 2003 Aug. PMID 14499357 Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. Kaye KM, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855313 Free PMC Article

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TANK Polyclonal Antibody, 100μg, (ATB-T4540)
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