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TCP-1 ε Polyclonal Antibody, 100μg, (ATB-T4584)

$199.00
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Background: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2010]Product datasheet: Overview Product Description TCP-1 ε Polyclonal Antibody, 100μg, (ATB-T4584) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human TCP-1 ε. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia. Bouhouche A, et al. J Med Genet, 2006 May. PMID 16399879 Free PMC Article Identification of differentially expressed genes in classical and atypical multidrug-resistant gastric carcinoma cells. Ludwig A, et al. Anticancer Res, 2002 Nov-Dec. PMID 12530067 Differential expression of molecular chaperones in brain of patients with Down syndrome. Yoo BC, et al. Electrophoresis, 2001 Apr. PMID 11358150 Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy. Sergeeva OA, et al. J Biol Chem, 2014 Oct 3. PMID 25124038 Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers. Sergeeva OA, et al. J Biol Chem, 2013 Jun 14. PMID 23612981 Free PMC Article

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TCP-1 ε Polyclonal Antibody, 100μg, (ATB-T4584)
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