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TFIIA-α Polyclonal Antibody, 100μg, (ATB-T4614)

$199.00
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Background: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]Product datasheet: Overview Product Description TFIIA-α Polyclonal Antibody, 100μg, (ATB-T4614) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human TFIIA-α. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. Høiby T, et al. EMBO J, 2004 Aug 4. PMID 15257296 Free PMC Article Human genome search in celiac disease: mutated gliadin T-cell-like epitope in two human proteins promotes T-cell activation. Kumar R, et al. J Mol Biol, 2002 Jun 7. PMID 12054857 Identification of candidate epigenetic biomarkers for ovarian cancer detection. Huang YW, et al. Oncol Rep, 2009 Oct. PMID 19724865 Free PMC Article TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability. Hieb AR, et al. J Mol Biol, 2007 Sep 21. PMID 17681538 Interaction of polymorphisms in the interleukin 1B-31 and general transcription factor 2A1 genes on the susceptibility to gastric cancer. Lee KA, et al. Cytokine, 2007 May. PMID 17596959

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TFIIA-α Polyclonal Antibody, 100μg, (ATB-T4614)
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