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TFIIH p44 Polyclonal Antibody, 100μg, (ATB-T4617)
Background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description TFIIH p44 Polyclonal Antibody, 100μg, (ATB-T4617) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human TFIIH p44. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Impairment of alveolar macrophage transcription in idiopathic pulmonary fibrosis. Ren P, et al. Am J Respir Crit Care Med, 2007 Jun 1. PMID 17332483 Free PMC Article A role of the C-terminal part of p44 in the promoter escape activity of transcription factor IIH. Tremeau-Bravard A, et al. J Biol Chem, 2001 Jul 20. PMID 11319235 A multicopy transcription-repair gene, BTF2p44, maps to the SMA region and demonstrates SMA associated deletions. Carter TA, et al. Hum Mol Genet, 1997 Feb. PMID 9063743 The gene encoding p44, a subunit of the transcription factor TFIIH, is involved in large-scale deletions associated with Werdnig-Hoffmann disease. Bürglen L, et al. Am J Hum Genet, 1997 Jan. PMID 8981949 Free PMC Article The multiple roles of transcription/repair factor TFIIH. Svejstrup JQ, et al. Trends Biochem Sci, 1996 Sep. PMID 8870499
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At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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- Protective gear
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