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TNAP Polyclonal Antibody, 100μg, (ATB-T4683)
Background: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]Product datasheet: Overview Product Description TNAP Polyclonal Antibody, 100μg, (ATB-T4683) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human TNAP. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Clinical and genetic aspects of hypophosphatasia in Japanese patients. Taketani T, et al. Arch Dis Child, 2014 Mar. PMID 24276437 Alkaline phosphatase: the next independent predictor of the poor 90-day outcome in alcoholic hepatitis. Kasztelan-Szczerbinska B, et al. Biomed Res Int, 2013. PMID 24151614 Free PMC Article Characterization of six missense mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in Chinese children with hypophosphatasia. Yang H, et al. Cell Physiol Biochem, 2013. PMID 24022022 Novel ALPL genetic alteration associated with an odontohypophosphatasia phenotype. Martins L, et al. Bone, 2013 Oct. PMID 23791648 Free PMC Article Functional evaluation of mutations in the tissue-nonspecific alkaline phosphatase gene. Zhu T, et al. Chin J Dent Res, 2012. PMID 23509830
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At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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