TNF-β Polyclonal Antibody, 100µg, (ATB-T4691)

Background: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.Product datasheet: Overview Product Description TNF-β Polyclonal Antibody, 100µg, (ATB-T4691) Species Reactivities Human,Mouse,Rat,Monkey Immunogen Synthesized peptide derived from the Internal region of human TNF-β. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome. Nedospasov S.A., Shakhov A.N., Turetskaya R.L., Mett V.A., Azizov M.M., Georgiev G.P., Korobko V.G., Dobrynin V.N., Filippov S.A., Bystrov N.S., Boldyreva E.F., Chuvpilo S.A., Chumakov A.M., Shingarova L.N., Ovchinnikov Y.A.Cold Spring Harb. Symp. Quant. Biol. 51:611-624(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Structure and chromosomal localization of the human lymphotoxin gene. Nedwin G.E., Jarrett-Nedwin J., Smith D.H., Naylor S.L., Sakaguchi A.Y., Goeddel D.V., Gray P.W.J. Cell. Biochem. 29:171-181(1985) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma. Kobayashi Y., Miyamoto D., Asada M., Obinata M., Osawa T.J. Biochem. 100:727-733(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. Gray P.W., Aggarwal B.B., Benton C.V., Bringman T.S., Henzel W.J., Jarrett J.A., Leung D.W., Moffat B., Ng P., Svedersky L.P., Palladino M.A., Nedwin G.E.Nature 312:721-724(1984) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta from B lymphoblastoid cell RPMI 1788. Matsuyama N., Okawa N., Tsukii Y., Endo T., Kaji A.FEBS Lett. 302:141-144(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. Iris F.J.M., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V., Jurka J., Rodriguez-Tome P., Claverie J.-M., Dausset J., Cohen D.Nat. Genet. 3:137-145(1993) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. Neville M.J., Campbell R.D.J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region. Shiina S., Tamiya G., Oka A., Inoko H.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. SeattleSNPs variation discovery resourceSubmitted (DEC-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-13; PRO-51 AND ASN-60.