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TSC-22 Polyclonal Antibody, 100μg, (ATB-T4758)

$199.00
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Product Details

Background: This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]Product datasheet: Overview Product Description TSC-22 Polyclonal Antibody, 100μg, (ATB-T4758) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human TSC-22. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Regulation of TGF-β signaling by PKC depends on Tsc-22 inducibility. Ahn H, et al. Mol Cell Biochem, 2012 Jan. PMID 21881999 Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence. Hömig-Hölzel C, et al. EMBO J, 2011 May 4. PMID 21448135 Free PMC Article Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: implications for tumor cell differentiation. Doi Y, et al. Oncol Rep, 2008 Mar. PMID 18288391 Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer. Rentsch CA, et al. Int J Cancer, 2006 Feb 15. PMID 16106424 Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1. Uchida D, et al. Biochem Biophys Res Commun, 2003 Jun 13. PMID 12767908

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TSC-22 Polyclonal Antibody, 100μg, (ATB-T4758)
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