TSLC1 Polyclonal Antibody, 100µg, (ATB-T4764)

Background: Mediates homophilic cell-cell adhesion in a Ca ²⁺ -independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca ²⁺ -independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.Product datasheet: Overview Product Description TSLC1 Polyclonal Antibody, 100µg, (ATB-T4764) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the C-terminal region of human TSLC1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Zhou Y., Du G., Hu X., Yu S., Liu Y., Xu Y., Huang X., Liu J., Yin B., Fan M., Peng X., Qiang B., Yuan J.Biochim. Biophys. Acta 1669:142-154(2005) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion. Moiseeva E.P., Leyland M.L., Bradding P.Cell. Mol. Life Sci. 69:2751-2764(2012) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING. Tissue: Mast cell. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Corominas R., Yang X., Lin G.N., Kang S., Shen Y., Ghamsari L., Broly M., Rodriguez M., Tam S., Wanamaker S.A., Fan C., Yi S., Tasan M., Lemmens I., Kuang X., Zhao N., Malhotra D., Michaelson J.J. , Vacic V., Calderwood M.A., Roth F.P., Tavernier J., Horvath S., Salehi-Ashtiani K., Korkin D., Sebat J., Hill D.E., Hao T., Vidal M., Iakoucheva L.M.Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5). Tissue: Fetal brain. Cloning of a secretory isoform of SgIGSF/TSLC-1. Ito A., Koma Y., Nagano T.Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: LungImported

Manually validated information which has been imported from another database.

More…