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Tak1 Polyclonal Antibody, 100μg, (ATB-T4535)

$199.00
In stock
Product Details

Background: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Tak1 Polyclonal Antibody, 100μg, (ATB-T4535) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Tak1 around the non-phosphorylation site of T184. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Identification of TGF-β-activated kinase 1 as a possible novel target for renal cell carcinoma intervention. Meng F, et al. Biochem Biophys Res Commun, 2014 Oct 10. PMID 25261726 TAK1 regulates hepatic cell survival and carcinogenesis. Roh YS, et al. J Gastroenterol, 2014 Feb. PMID 24443058 Free PMC Article Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial-mesenchymal transition of cancer cells. Lam CR, et al. Cell Death Dis, 2013 Oct 10. PMID 24113182 Free PMC Article TGF-β-activated kinase-1: a potential prognostic marker for clear cell renal cell carcinoma. Wei C, et al. Asian Pac J Cancer Prev, 2013. PMID 23534745 Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions. Kluth M, et al. Mod Pathol, 2013 Jul. PMID 23370768

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Tak1 Polyclonal Antibody, 100μg, (ATB-T4535)
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