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Tau Polyclonal Antibody, 100μg, (ATB-T4553)

$199.00
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Background: This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Tau Polyclonal Antibody, 100μg, (ATB-T4553) Image Species Reactivities Human,Mouse,Rat,Monkey Immunogen Synthesized peptide derived from human Tau around the non-phosphorylation site of S235. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Resonance Raman spectroscopic measurements delineate the structural changes that occur during tau fibril formation. Ramachandran G, et al. Biochemistry, 2014 Oct 21. PMID 25284680 Tau binds to lipid membrane surfaces via short amphipathic helices located in its microtubule-binding repeats. Georgieva ER, et al. Biophys J, 2014 Sep 16. PMID 25229151 Serum-induced neurite retraction in CAD cells--involvement of an ATP-actin retractile system and the lack of microtubule-associated proteins. Chesta ME, et al. FEBS J, 2014 Nov. PMID 25112570 The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice. Li C, et al. Anesth Analg, 2014 Aug. PMID 24977637 Free PMC Article Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses. Rudinskiy N, et al. Acta Neuropathol Commun, 2014 Jun 10. PMID 24915991 Free PMC Article

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Tau Polyclonal Antibody, 100μg, (ATB-T4553)
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