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UBA1 Polyclonal Antibody, 100μg, (ATB-T15493)

$199.00
In stock
Product Details

Background: The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description UBA1 Polyclonal Antibody, 100μg, (ATB-T15493) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human UBA1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage. Moudry P, et al. Cell Cycle, 2012 Apr 15. PMID 22456334 Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1). Ungermannova D, et al. PLoS One, 2012. PMID 22279528 Free PMC Article Spinal Muscular Atrophy, X-Linked Infantile Baumbach-Reardon L, et al. , 1993. PMID 20301739 UBE1 expression in extranodal NK/T cell lymphoma, nasal type. Su ZL, et al. Leuk Lymphoma, 2008 Sep. PMID 18661401 Rare missense and synonymous variants in UBE1 are associated with X-linked infantile spinal muscular atrophy. Ramser J, et al. Am J Hum Genet, 2008 Jan. PMID 18179898 Free PMC Article

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UBA1 Polyclonal Antibody, 100μg, (ATB-T15493)
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