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USP16 Polyclonal Antibody, 100μg, (ATB-T4831)

$199.00
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Product Details

Background: This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description USP16 Polyclonal Antibody, 100μg, (ATB-T4831) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human USP16. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Usp16 contributes to somatic stem-cell defects in Down's syndrome. Adorno M, et al. Nature, 2013 Sep 19. PMID 24025767 Free PMC Article Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. Gelsi-Boyer V, et al. BMC Cancer, 2008 Oct 16. PMID 18925961 Free PMC Article A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division. Cai SY, et al. Proc Natl Acad Sci U S A, 1999 Mar 16. PMID 10077596 Free PMC Article The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage. Zhang Z, et al. J Biol Chem, 2014 Nov 21. PMID 25305019 Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. Pai MT, et al. J Mol Biol, 2007 Jul 6. PMID 17512543 Free PMC Article

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USP16 Polyclonal Antibody, 100μg, (ATB-T4831)
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