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USP44 Polyclonal Antibody, 100μg, (ATB-T4841)

$199.00
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Product Details

Background: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]Product datasheet: Overview Product Description USP44 Polyclonal Antibody, 100μg, (ATB-T4841) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human USP44. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. Zhang Y, et al. PLoS One, 2011. PMID 21853124 Free PMC Article K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44. Suresh B, et al. Cell Biol Int, 2010 Aug. PMID 20402667 The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases. Mosbech A, et al. J Biol Chem, 2013 Jun 7. PMID 23615962 Free PMC Article Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. Visconti R, et al. Nat Commun, 2012 Jun 12. PMID 22692537 Free PMC Article Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Stegmeier F, et al. Nature, 2007 Apr 19. PMID 17443180

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USP44 Polyclonal Antibody, 100μg, (ATB-T4841)
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