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VHL Polyclonal Antibody, 100μg, (ATB-T4876)
Background: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description VHL Polyclonal Antibody, 100μg, (ATB-T4876) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human VHL around the non-phosphorylation site of S68. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma. Alves MR, et al. Virchows Arch, 2014 Sep. PMID 25027579 von Hippel-Lindau exonic methylation analysis using MALDI-TOF mass spectrometry. Lian F, et al. J Urol, 2014 Nov. PMID 24704013 De novo VHL germline mutation detected in a patient with mild clinical phenotype of von Hippel-Lindau disease. Ding X, et al. J Neurosurg, 2014 Aug. PMID 24678776 The multifaceted von Hippel-Lindau tumour suppressor protein. Robinson CM, et al. FEBS Lett, 2014 Aug 19. PMID 24583008 Higher prevalence of novel mutations in VHL gene in Chinese Von Hippel-Lindau disease patients. Wang X, et al. Urology, 2014 Mar. PMID 24581539
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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