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abin Science InVivoMAb Anti-Human IL-11 Antibody (X203), HB978010-50UG
Overview
| Catalog No. | HB978010-50UG |
|---|---|
| Description | InVivoMAb Anti-Human IL11 Antibody (X203) [X203] (HB978010-50UG) is a mouse monoclonal antibody detecting Interleukin-11
in FuncS. Suitable for Human.
|
| Species reactivity | Human |
| Applications | FuncS |
| Host species | Mouse |
| Isotype | IgG2a, kappa |
| Clone ID | X203 |
| Clonality | Monoclonal |
| Target | Interleukin-11, IL-11, Adipogenesis inhibitory factor, AGIF, Oprelvekin, IL11 |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | P20809 |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578
2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066
3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
Images
SDS-PAGE
SDS-PAGE for InVivoMAb Anti-Human IL11 Antibody (X203)
Bioactivity
Detects recombinant human IL11-SUMO (Catalog No: HB978022 ) in indirect ELISA
Western blot
Western blot analysis was performed using anti-IL11 monoclonal antibody at 1ug/mL on various samples.
Data Sheet
https://www.abinscience.com/index/pdf?id=18692