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hnRNP L Polyclonal Antibody, 100μg, (ATB-T2203)
Background: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description hnRNP L Polyclonal Antibody, 100μg, (ATB-T2203) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the Internal region of human hnRNP L. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Crosslinking-immunoprecipitation (iCLIP) analysis reveals global regulatory roles of hnRNP L. Rossbach O, et al. RNA Biol, 2014 Feb. PMID 24526010 Free PMC Article Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T cells. Shankarling G, et al. Mol Cell Biol, 2014 Jan. PMID 24164894 Free PMC Article Autoantibody recognition of an N-terminal epitope of hnRNP L marks the risk for developing HBV-related hepatocellular carcinoma. Yau WY, et al. J Proteomics, 2013 Dec 6. PMID 24125732 Minimal functional domains of paralogues hnRNP L and hnRNP LL exhibit mechanistic differences in exonic splicing repression. Shankarling G, et al. Biochem J, 2013 Jul 15. PMID 23646903 Free PMC Article HnRNPL as a key factor in spermatogenesis: Lesson from functional proteomic studies of azoospermia patients with sertoli cell only syndrome. Li J, et al. J Proteomics, 2012 Jun 6. PMID 22245417
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