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hnRNP M Polyclonal Antibody, 100μg, (ATB-T2205)

$199.00
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Product Details

Background: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]Product datasheet: Overview Product Description hnRNP M Polyclonal Antibody, 100μg, (ATB-T2205) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human hnRNP M. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. Xu Y, et al. Genes Dev, 2014 Jun 1. PMID 24840202 Free PMC Article Identification of HnRNP M as a novel biomarker for colorectal carcinoma by quantitative proteomics. Chen S, et al. Am J Physiol Gastrointest Liver Physiol, 2014 Mar 1. PMID 24381081 Cloning and characterization of a novel deletion mutant of heterogeneous nuclear ribonucleoprotein M4 from human dendritic cells. Huang X, et al. Sci China C Life Sci, 2000 Dec. PMID 18726360 Surface expression of heterogeneous nuclear RNA binding protein M4 on Kupffer cell relates to its function as a carcinoembryonic antigen receptor. Bajenova O, et al. Exp Cell Res, 2003 Nov 15. PMID 14597422 The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping. Gattoni R, et al. Nucleic Acids Res, 1996 Jul 1. PMID 8692693 Free PMC Article

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hnRNP M Polyclonal Antibody, 100μg, (ATB-T2205)
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