β-1,3-Gal-T4 Polyclonal Antibody, 100μg, (ATB-T5004)

Background: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description β-1,3-Gal-T4 Polyclonal Antibody, 100μg, (ATB-T5004) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human β-1,3-Gal-T4. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function. Dong L, et al. Glycoconj J, 2011 May. PMID 21519903 Free PMC Article GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. Dong Y, et al. Cancer Sci, 2010 Sep. PMID 20594196 The beta-1,3-galactosyltransferase-4 (B3GALT4) gene is located in the centromeric segment of the human MHC class II region. Shiina T, et al. Immunogenetics, 2000 Jan. PMID 10663566 Beta1,3-galactosyltransferases-4/5 are novel tumor markers for gynecological cancers. Seko A, et al. Tumour Biol, 2009. PMID 19225246 A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family. Amado M, et al. J Biol Chem, 1998 May 22. PMID 9582303